2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. GABA Receptor

GABA Receptor

Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor

GABA Receptor

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GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-U00315S
    Gidazepam-d5
    		Antagonist
    Gidazepam-d5 is a deuterium labeled Gidazepam. Gidazepam is an agonist of GABA receptor channels (GABA RCs), and has anticonvulsant effect.
    Gidazepam-d<sub>5</sub>
  • HY-151951
    Antidepressant agent 4
    Antidepressant agent 4 is an orally active antidepressant agent. Antidepressant agent 4 exhibits antidepressant, anxiolytic, performance enhancing and nootropic activities.
    Antidepressant agent 4
  • HY-103499
    ZK 93426 hydrochloride
    		Antagonist
    ZK 93426 (hydrochloride) is a benzodiazepine antagonist. ZK 93426 (hydrochloride) can be used for the research of neurological disease.
    ZK 93426 hydrochloride
  • HY-114076
    CGP55845
    CGP55845 is a potent and selective GABAB receptor antagonist with activity that blocks agonist binding. The IC50 value of CGP55845 is 5 nM, indicating that it exhibits significant activity in inhibiting GABA and glutamate release. The apparent Kd of CGP55845 when forming a complex with the GABAB receptor is 30 nM, indicating its high affinity for this receptor. CGP55845 is as potent as 100 μM CGP 35348 in relieving the inhibitory effect of (R)-(-)-baclofen.
    CGP55845
  • HY-100264
    Uldazepam
    Uldazepam is a benzodiazepine derivative and has the potential for anxiety syndrome treatment.
    Uldazepam
  • HY-108204
    AZD 3043
    AZD 3043 (THRX 918661) is a positive allosteric modulator of GABA(A) receptors with sedative and hypnotic activity. AZD 3043 can enhance GABA(A) receptor-mediated chloride currents in vitro and produce hypnotic and electroencephalographic inhibitory effects in vivo. Due to its esterase-dependent metabolic pathway, it has a short duration of action and can be quickly cleared even after long-term infusion, which may have clinical application potential.
    AZD 3043
  • HY-123489S
    3α,21-Dihydroxy-5α-pregnan-20-one-d3
    		Agonist
    3α,21-Dihydroxy-5α-pregnan-20-one-d3 is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
    3α,21-Dihydroxy-5α-pregnan-20-one-d<sub>3</sub>
  • HY-Z1085
    Deschloro-Zopiclone
    		Inhibitor
    Deschloro-Zopiclone is an impurity of Zopiclone. Zopiclone is the first non-benzodiazepine compound, which can enhance the activity of inhibitory neurotransmitter gamma amino butyric acid in the brain.
    Deschloro-Zopiclone
  • HY-115763
    3-Aminopropylphosphinic acid
    		Agonist
    3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist.
    3-Aminopropylphosphinic acid
  • HY-107323A
    Bentazepam hydrochloride
    Bentazepam (QM 6008, Thiadipone) hydrocholide is a compound with short-action anxiolytic effect. Bentazepam hydrocholide shows anticonvulsant and sedative properties. Bentazepam hydrocholide can be used for the research of depressive disorder and anxiety.
    Bentazepam hydrochloride
  • HY-B2177R
    Apronal (Standard)
    		Agonist
    Apronal (Standard) is the analytical standard of Apronal. This product is intended for research and analytical applications. Apronal (Allylisopropylacetylurea, Apronalide) can bu used for the research of neuropsychiatry disorders.
    Apronal (Standard)
  • HY-116152S2
    Cipepofol-d6-2
    		Activator
    Cipepofol-d6-2 (Ciprofol-d6-2; HSK3486-d6-2) is deuterium labeled Cipepofol (HY-116152). Cipepofol (HSK3486), a psychomotor stabilizing agent, is a gamma-aminobutyric acid (GABA) receptor potentiator.
    Cipepofol-d<sub>6</sub>-2
  • HY-103497
    U-89843A hydrochloride
    		Modulator
    U-89843A is an allosteric modulator of GABAA receptor. U-89843A enhances GABA-induced Cl- currents.
    U-89843A hydrochloride
  • HY-141672S1
    17β-Estradiol sulfate-d4 sodium
    		≥99.0%
    17β-Estradiol sulfate-d4 (sodium) is the deuterium labeled 17β-Estradiol sulfate 17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].
    17β-Estradiol sulfate-d<sub>4</sub> sodium
  • HY-170903
    GABAA receptor modulator-3
    		Agonist
    GABAA receptor modulator-3 (compound 3b) is a positive allosteric modulator (PAM). GABAA receptor modulator-3 inhibits α1β3γ2 GABAAR at peak and steady state currents with IC50s of 671 and 64 μM, respectively.
    GABAA receptor modulator-3
  • HY-160189
    3-Ethyl-3-methylthiolan-2-one
    		Inhibitor
    3-Ethyl-3-methylthiolan-2-one is an antiepileptic agent that inhibits GABAA receptors.
    3-Ethyl-3-methylthiolan-2-one
  • HY-118259
    L-663581
    		Agonist
    L-663581 (FG-8205) is an agonist of benzodiazepine receptor, acting as a partial agonist at GABA A receptor.
    L-663581
  • HY-W634748
    Desalkylgidazepam
    		Agonist
    Desalkylgidazepam is a benzodiazepine compound and Gidazepam (HY-U00315) metabolite. Desalkylgidazepam can activate GABA A receptor and translocator protein (TSPO).
    Desalkylgidazepam
  • HY-P5857
    MmTx2 toxin
    		Modulator
    MmTx2 toxin is a GABAA receptor modulator that enhances GABAA receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain.
    MmTx2 toxin
  • HY-170498
    GABA-A Receptor Ligand-1
    		Ligand
    GABA-A Receptor Ligand-1 (Compound 4) is a ligand for GABA-A receptor with a pKi of 7.27. GABA-A Receptor Ligand-1 reduces mitochondrial dysfunction, promotes neurite outgrowth and neuronal regeneration. GABA-A Receptor Ligand-1 exhibits neuroprotective efficacy in rats ischemic stroke models.
    GABA-A Receptor Ligand-1
Cat. No. Product Name / Synonyms Application Reactivity